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Christina Applegate Says She Was Misdiagnosed With Multiple Sclerosis

other · 2026-10-20

On her podcast "MeSsy," Christina Applegate disclosed that her doctor has informed her she does not actually have multiple sclerosis, indicating a previous misdiagnosis. The actress, who initially revealed her diagnosis of the autoimmune condition affecting the central nervous system in 2021, expressed that she feels she is "back at square one" and is uncertain about her health status. During a conversation with co-host Jamie-Lynn Sigler, who has openly discussed her own experiences with MS, Applegate mentioned that she continues to face "every symptom of someone with MS," including significant mobility challenges. She emphasized her reliance on wheelchairs at medical appointments and her inability to walk from the car to the office. This revelation was made in the latest episode of the podcast, released on Monday, after years of Applegate sharing her journey.

Key facts

  • Christina Applegate said on Monday her doctor now believes she was misdiagnosed with multiple sclerosis.
  • She first publicly announced her MS diagnosis in 2021.
  • Applegate said she is "back at square one" regarding her health.
  • She still reports "every symptom of someone with MS," including mobility issues.
  • Applegate said she uses wheelchairs at the doctor's office and cannot walk from the car to the room.
  • The disclosure was made on her podcast "MeSsy" with co-host Jamie-Lynn Sigler.
  • Sigler has been public about her own battle with MS.
  • MS is described as a disorder in which the immune system attacks cells of the central nervous system.

Entities

Artists

  • Christina Applegate
  • Jamie-Lynn Sigler
  • Jamie Sigler
  • Linda Cardellini
  • Marwa Kaisey

Institutions

  • MeSsy
  • Messy podcast
  • Netflix
  • Dead to Me
  • New York Times
  • BBC

Locations

  • Hollywood
  • Los Angeles
  • United States

Sources