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Volufiline Tested for Under-Eye Hollows: What It Can and Can't Do

other · 2026-07-17

Volufiline, a plant-derived compound containing sarsasapogenin, is gaining popularity on TikTok as a topical alternative to injectable fillers for under-eye hollows. Experts caution it is not a replacement for fillers but can provide subtle plumping effects by promoting lipid accumulation in fat cells. Jessica Manges, founder of LUX Injectables in Clearwater, FL, explains that volufiline offers modest cosmetic improvements in skin hydration and smoothness, not dramatic volume enhancement. Nurse Maro Mehdi from Alchemy 43 in Los Angeles recommends it for mild crepiness and fine lines. Vogue editors tested three products: Medicube PDRN Pink Collagen Volume Multi Balm Stick, The Ordinary Volufiline 92% + Pal-Isoleucine 1% Serum, and Abib PDRN Volume fill-it Booster Cream. The Ordinary's serum, with 92% volufiline, was praised for cumulative subtle benefits. Abib's cream, containing volufiline and PDRN, showed results on tech neck lines. The article includes expert insights from Jessica Manges, Maro Mehdi, and Tama Tran.

Key facts

  • Volufiline contains sarsasapogenin, a plant-derived compound that promotes lipid accumulation in fat cells.
  • Jessica Manges is founder and lead injector at LUX Injectables in Clearwater, FL.
  • Maro Mehdi is a registered nurse and aesthetic nurse injector at Alchemy 43 in Los Angeles, CA.
  • Tama Tran is a board-certified aesthetic nurse practitioner in Dallas.
  • Medicube PDRN Pink Collagen Volume Multi Balm Stick includes PDRN, volufiline 5%, low-molecular collagen, NAD, and liposomal EGF.
  • The Ordinary Volufiline 92% + Pal-Isoleucine 1% Serum contains 92% volufiline and palmitoyl isoleucine.
  • Abib PDRN Volume fill-it Booster Cream contains PDRN (15,000 ppm), volufiline (10,000 ppm), retinal, and peptides.
  • Vogue editors Kiana Murden and Concetta Ciarlo tested the products.

Entities

Institutions

  • Vogue
  • LUX Injectables
  • Alchemy 43
  • Medicube
  • The Ordinary
  • Abib

Locations

  • Clearwater
  • Florida
  • Los Angeles
  • California
  • Dallas
  • Texas

Sources