Eating Boosts T Cell Immune Response, New Study Finds
A new study published in Nature reveals that eating meals immediately boosts the immune system's T cells. Researchers at the University of Pittsburgh drew blood from 31 healthy volunteers after fasting overnight and again after breakfast and lunch, finding that fed T cells were better prepared to fight infections. Mouse experiments confirmed the effect, with fed mice showing larger mitochondria, more fat reserves, and greater sugar uptake. A fat-rich diet (corn oil) produced the strongest response in mice. The study suggests timing of meals could impact vaccine efficacy and CAR T-cell therapy outcomes. Senior author Greg Delgoffe noted that chylomicrons, which carry fats in the bloodstream, may fuel enhanced T cells. The research points to a previously overlooked factor in medical studies.
Key facts
- Study published in Nature journal
- 31 healthy volunteers participated
- Blood drawn after fasting and after meals
- Fed T cells outperformed fasted T cells in fighting infections
- Mouse experiments showed similar results
- Fat-rich diet (corn oil) boosted T cells best in mice
- Findings may affect vaccine timing and CAR T-cell therapy
- Chylomicrons identified as potential fuel for T cell boost
Entities
Institutions
- University of Pittsburgh
- Indiana University
- Nature
- Smithsonian Magazine
- Washington Post
- Scientific American
Locations
- Pittsburgh
- United States